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. 2018 Aug 8;9:1104. doi: 10.3389/fphys.2018.01104

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Copyright © 2018 Sun, Huang, Yan, Li, Liu, Wei, Cui, Pan, Fan, Wang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sch inhibits FoxO1 activation at 8 h after the termination of LPS infusion. (A,B) Representative Western blots and quantitative analysis of FoxO1 expression in cytoplasm (A) and nuclei (B) in different groups. (C,D) Representative Western blots and quantitative analysis of p27^kip1 (C) and p21^cip1 (D) in different groups. (E,F) Representative Western blots and quantitative analysis of FoxO1 (E) and Akt (F) phosphorylation in different groups. Values are expressed as mean ± SD of 5 separate experiments. Sham, sham group; Sch, sch alone group; LPS, LPS infusion for 90 min group; Sch + LPS, Sch pretreatment at 2.5 mg/kg/h followed by LPS infusion for 90 min group. ^∗p < 0.05 vs. Sham group, ^#p < 0.05 vs. LPS group.