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. 2018 Aug 7;61(16):7261–7272. doi: 10.1021/acs.jmedchem.8b00782

Scheme 1. General Route to Quinazolinone Derivatives.

Scheme 1

(a) 110 °C, 16–100%; (b) PdCl2(PPh3)2, NaOH(aq), 1,4-dioxane, 120–150 °C, 12–100%.