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. 2018 Aug 7;61(16):7261–7272. doi: 10.1021/acs.jmedchem.8b00782

Scheme 2. Synthesis of 2-Benzyl Quinazolinones.

Scheme 2

(a) (i) 50% NH2OH(aq), 120 °C, (ii) 25, 150 °C, 24%; (b) PdCl2(PPh3)2, NaOH(aq), 1,4-dioxane, 100 °C, 51–100%.