Figure 1.

Arrangement of Trp residues in MSG. A, cartoon representation of MSG (PDB code 1D8C) is shown to contain four domains: α-helical clasp (magenta); β-sheet domain (salmon); TIM barrel domain (cyan); and the C-terminal cap (blue) covering the active site. The residues in gray represent the inter-domain–connecting region in the sequence. The Trp residues are shown in yellow (with spherical heavy atoms) for distinction. B, amino acids sequence is colored in accordance with the domains shown in structure.