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. 2018 Aug 13;4(2):e000468. doi: 10.1136/rmdopen-2017-000468

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0

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Exemplar rats with high body fat and high weight (left), high body fat and normal weight (middle) and normal body fat and normal weight (right) and associated exemplar histological samples of the knee following 28 weeks on a HFS diet (left and middle rats) and a normal control diet (right rat). Note that the severity of knee joint degeneration is similar in the rats with the high percentage of body fat (left and middle), despite unequal body weight, while joint degeneration is substantially greater in the middle compared with the right rat despite similar body weight but unequal body fat percentage. HFS, high-fat, high-sucrose.