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. Author manuscript; available in PMC: 2018 Aug 27.
Published in final edited form as: Ann Rheum Dis. 2016 Aug 19;76(3):602–611. doi: 10.1136/annrheumdis-2016-209683

Figure 3. Lupus HDL binds LOX1R, blocks ATF3 nuclear translocation and promotes inflammatory cytokine synthesis.

Figure 3.

(A) Pre-incubation with blocking anti-LOX1R antibody (anti-LOX1R) increases ATF3 nuclear translocation in CMϕ (N=12) exposed to SLE HDL (N=7) for 30min compared to isotype control (Iso). Images are representative of conditions performed in triplicate. Bar graph represents percent of ATF3 that co-localizes with DNA by weighted co-localization coefficient. Anti-LOX1R modifies (B) IL-6 and (C) TNF secretion by CMϕ (N=12) exposed overnight to SLE (N=10), but not Ctrl HDL (N=6). Bar graphs are mean ± SEM, ** p<0.01, *** p<0.0005, **** p<0.0001.