Maximum anti-Sm-p80 antibody titers in baboons following vaccination. (A) Maximum total IgG titers achieved by each baboon in trials 1–4, (B) Maximum IgM titers, (C) Maximum IgG1 titers and (D) maximum IgA titers for each baboon in Trials 1, 2, 3, and 4. “C” represents the control group (GLA-SE), while “E” represents the experimental group (rSm-p80 + GLA-SE). Serum samples were obtained from each baboon prior to immunizations, parasite challenge and at necropsy.