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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Ann N Y Acad Sci. 2018 Aug;1425(1):38–51. doi: 10.1111/nyas.13942

Fig. 6.

Fig. 6.

Systems biology approach to identify molecular signatures in PBMCs, lymph nodes, and spleen. (A) Venn diagram depicting numbers and percentages of significant differentially expressed genes (DEGs) (p<0.05; 1.5-fold change cutoff) in Sm-p80–immunized baboon PBMCs, lymph nodes, and spleen at necropsy. (B) Distribution of DEGs (y-axis) in Sm-p80–immunized baboon PBMCs and secondary lymphoid tissues, as well as DEGs common to all tissues at necropsy according to ontology classification. (C) Heat map depicting IPA-identified common canonical pathways with activation z-score for which scores were available and not zero. (D) Heat map depicting IPA-identified common upstream regulators with activation z-scores for which scores were available and not zero. (E) Gene network derived from immune-related DEGs in baboon lymph nodes at necropsy. (F) Gene network derived from immune-related DEGs in baboon spleen at necropsy.