Skip to main content
. Author manuscript; available in PMC: 2019 Aug 28.
Published in final edited form as: J Am Coll Cardiol. 2018 Aug 28;72(9):1015–1026. doi: 10.1016/j.jacc.2018.06.044

Central Illustration. Remote Endothelial Activation after Myocardial Infarction.

Central Illustration

Myocardial infarction triggers systemic effects, including an increase in reactive oxygen species (ROS) and other damage-associated molecular patterns (DAMPs). These molecular intermediates result in endothelial activation including upregulation of adhesion molecules for inflammatory cells, increase in endothelial associated VWF, and secondary platelet adhesion. The pro-inflammatory and pro-thrombotic endothelial changes found in our experiments are changes could be associated with increased risk for atherothrombotic events in humans.