Table 1.
Characteristics of the study patients (N=121)
| Characteristics | COPD (n=65) | ACO (n=56) | P-value |
|---|---|---|---|
| Age (years) | 72.3 (±9.8) | 72.3 (±7.8) | 0.608 |
| Sex (M/F) | 54/11 | 42/14 | 0.368 |
| BMI (kg/m2) | 23.0 (±3.7) | 22.6 (±5.6) | 0.679 |
| Smoking status | |||
| Current smoker | 14 (21.5%) | 12 (21.4%) | 1.000 |
| Ex-smoker | 48 (73.8%) | 40 (71.4%) | |
| Pack-years | 56.0 (±31.6) | 46.4 (±30.0) | 0.048 |
| FVC (L) | 3.15 (±0.80) | 3.04 (±0.77) | 0.464 |
| FEV1 (L) | 1.72 (±0.56) | 1.55 (±0.51) | 0.141 |
| %FEV1 (%) | 69.7 (±21.1) | 64.9 (±17.6) | 0.283 |
| ICS use | 8 (12.3%) | 23 (41.1%) | 0.0004 |
| Comorbidity | |||
| Hypertension | 35 (53.8%) | 31 (55.4%) | 1.000 |
| Diabetes mellitus | 16 (24.6%) | 12 (21.4%) | 0.829 |
| Cardiovascular diseasea | 8 (12.3%) | 6 (10.7%) | 1.000 |
| FeNO (ppb) | 16.0 (12.0–20.0) | 24.5 (14.0–39.5) | 0.0012 |
| Eo (cells/μL) | 138.0 (90.0–207.5) | 240.0 (127.5–310.0) | 0.0142 |
Notes: Data are shown as medians (interquartile range) or means ± SD or number (%).
a
Cardiovascular disease includes coronary artery diseases such as angina and myocardial infarction.
Abbreviations: ACO, asthma–COPD overlap; BMI, body mass index; Eo, eosinophils; FeNO, fractional exhaled nitric oxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; ICS, inhaled corticosteroids.