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. 2018 Aug 20;9:1949. doi: 10.3389/fmicb.2018.01949

Table 2.

The efficiency of RB-mediated photodynamic inactivation of P. aeruginosa clinical isolates in the presence and in the absence of PEX.

Strain Log10 reduction in survival of bacterial cells after treatment witha:
RB
 PEX
 RB+PEX
 Light only Antibiotic resistance statusb
Light Dark Light Dark Light Dark
1 10145 0.21 0.13 3.34 2.70 5.69 2.68 0.20
2 3042/s 0.44 −0.12 6.45 6.45 6.45 6.45 0.03
3 3318/p 0.48 −0.01 5.82 5.82 5.82 5.82 0.14
4 2969/s 0.35 0.25 6.12 4.49 6.12 6.12 0.20
5 1561/o 1.11 0.14 1.46 1.33 5.37 2.25 0.42 MDR
6 3404/p 0.81 0.03 5.37 5.37 5.37 5.37 0.36
7 3117/s 0.35 0.19 6.04 6.04 6.04 6.04 0.30
8 3146/s 0.63 0.18 1.97 1.48 5.90 2.18 0.43
9 4190/p A 0.58 0.41 3.44 2.61 6.43 3.07 0.54 MDR
10 1959/o 0.43 0.21 0.98 0.85 5.05 5.05 0.12 XDR
11 3109/o −0.08 −0.11 5.13 5.13 5.13 5.13 0.01 MDR
12 1286/o 0.36 0.24 0.56 0.55 5.42 2.70 0.19
13 55/K 0.44 0.24 5.27 5.27 5.27 5.27 0.21 XDR
14 978/K 0.69 −0.08 5.75 2.79 5.75 5.75 0.49 XDR
15 K3 1.10 0.14 5.95 5.95 5.95 5.95 0.02 MDR
16 K4 0.12 0.05 6.04 6.04 6.04 6.04 0.07 XDR
17 792/K 1.16 0.20 5.14 5.14 5.14 5.14 0.37 MDR
18 393/K 1.54 0.19 5.17 2.87 5.17 2.77 0.31
19 133/K −0.10 0.00 0.23 0.31 5.02 3.22 0.02
20 23/K 0.90 0.23 0.67 0.55 5.90 5.90 0.49
21 887/K 0.68 0.34 5.62 5.62 5.62 5.62 0.49 XDR
22 169/K 2.06 −0.02 2.37 0.52 5.98 5.98 0.07 XDR
23 3752/sz 1.12 0.14 5.85 5.85 5.85 5.85 0.05
24 4908/p 0.02 −0.37 1.96 1.63 4.88 2.07 0.00
25 3907/sz 0.92 0.07 3.09 2.37 5.29 3.56 0.86
26 15/p I 1.12 0.32 5.64 5.64 5.64 5.64 0.16
27 149/p 0.78 0.44 0.46 0.47 5.97 2.64 0.49
28 153/s 0.20 0.10 0.49 0.35 6.44 3.38 0.20
29 547/p 0.37 0.48 2.89 1.64 5.81 4.02 0.14
30 1885/K 0.79 0.51 1.12 0.83 6.05 2.04 0.09 XDR
31 556/K 0.46 0.29 0.67 0.27 5.41 1.93 0.25 XDR
32 1651/p 0.74 0.22 0.46 −0.28 5.46 2.42 0.03
33 1304/s 1.25 0.33 5.70 5.70 5.70 5.70 0.65 MDR
34 1804/p 1.08 0.01 5.26 2.60 5.26 2.37 0.25
35 2284/p 0.87 0.41 1.04 0.97 5.38 2.14 0.09
36 143/p 0.93 0.50 2.95 2.27 5.83 3.07 0.61

aThe values were calculated by subtracting log10 CFU/ml of treated samples from those of untreated controls (0 J/cm2; 0 μM RB, 0 μM PEX). The following concentration of compounds was used: 5 μM RB, 5 μM PEX, fluence 30 J/cm2. The initial number of cells was ∼106 CFU/ml. The presented values are mean of three independent experiments. bMDR (multidrug resistant), XDR (extended drug resistant), see Section “Materials and Methods” for classification details.