Table 1. The characteristics of different types of CircRNA.
Name | Type | Location | Joint site | Sequence feature | Function |
---|---|---|---|---|---|
ecRNA (Zhang et al., 2014) | exon | cytoplasms | 3′–5′ phosphodiester bond | Formed by cyclization of exons containing the reverse complementary sequence of introns and selective cyclization. | Functioning as miRNA sponges; Interact with RNA-binding proteins (RBPs); Participates in translation. |
CiRNA (Zhang et al., 2013) | intron | nucleus | 2′-5′ phosphodiester bond | 5′ splice site enriched with 7 GU motifs and 3′ branch site contains 11 C motifs. | Regulation of gene transcription. |
ElciRNA (Li et al., 2017b) | exon–intron | nucleus | 3′-5′ phosphodiester bond | Formed by cyclization of exons containing the reverse complementary sequence of introns and selective cyclization. | Regulation of gene transcription. |
Notes:
ecRNA, exon circRNA; ciRNA, intron circRNA; ElciRNA, exon-intron circRNA.