Table 1.
Clinical characteristics of study population
| Phenotype/covariate | Participants, N = 42 |
|---|---|
| Gender | |
| Female, no. (%) | 11 (26) |
| Male, no. (%) | 31 (74) |
| Age | |
| Years, mean ± SD | 9.22 ± 4.5 |
| 1–4 years old, n (%) | 9 (21) |
| 5–8 years old, n (%) | 9 (21) |
| 9–14 years old, n (%) | 23 (57) |
| Signs or symptoms at enrollment | |
| Days post‐symptom onset, mean ± SD | 1.41 ± 0.5 |
| Fever, mean temperature ± SD, °C | 38.3 ± 0.8 |
| Fever, mean duration ± SD, days | 2.4 ± 0.6 |
| High fever, peak temperature > 38.5°C, n (%) | 16 (38) |
| Retroorbital pain, n (%) | 7 (16) |
| Osteomuscular pain, n (%) | 26 (62) |
| Rash, n (%) | 41 (98) |
| Arthralgia, n (%) | 36 (86) |
| Myalgia, n (%) | 20 (48) |
| Headache, n (%) | 9 (21) |
| Abdominal pain, n (%) | 13 (31) |
| Vomiting, n (%) | 4 (10) |
| Fluid accumulation, n (%) | 14 (33) |
| Hospitalized, n (%) | 36 (86) |
| Laboratory values at enrollment | |
| Median platelet count, mm−3 (range) | 199,000 (88,000–337,000) |
| Nadir platelet count < 100,000 mm−3, n (%) | 8 (19) |
| Median white cell count, mm−3 (range) | 8,140 (3,030–16,120) |
| Median monocyte % of WBCs (range) | 8.9 (4.1–14.6) |
| Median lymphocyte % of WBCs (range) | 39.7 (10.4–66.4) |
| Laboratory values at convalescent timepoint | |
| Days post‐symptom onset, mean ± SD | 15.7 ± 0.6 |
| Median CHIKV Ab titer, dilutions (range) | 1,458 (232–7,794) |
| Severity categorizationa | |
| More severe (%) | 21 (50) |
| Less severe (%) | 21 (50) |
WBC, white blood cell; CHIKV, chikungunya virus; Ab, antibody.
a
Cases were categorized as more severe if the patient had either a peak fever of >38.5°C or a nadir platelet count of < 100,000 mm−3.