Table 2. QCA analysis of serial angiography at baseline, 1 year and long-term follow-up after heart transplantation.
| All patients | At 1 year | p-value | At long-term follow-up | p-value | |||
|---|---|---|---|---|---|---|---|
| ISHLT-CAV0 | ISHLT-CAV1-3 | ISHLT-CAV0 | ISHLT-CAV1-3 | ||||
| Number of patients | 41 | 32 | 9 | 16 | 25 | ||
| Number of segments | 520 | 408 | 112 | 204 | 316 | ||
| Number of segments per patient | 12.7 | 12.8 | 12.4 | 12.8 | 12.6 | ||
| Reference Vessel Diameter (mm) | |||||||
| Baseline | 3.10 [3.06 to 3.15] | 3.10 [3.05 to 3.15] | 3.12 [3.02 to 3.22] | 0.91 | 3.13 [3.06 to 3.21] | 3.09 [3.02 to 3.15] | 0.74 |
| 1-year | 3.04 [2.97 to 3.12] | 2.97 [2.89 to 3.06] | 3.29 [3.13 to 3.44] | 0.26 | 3.09 [2.97 to 3.21] | 3.01 [2.91 to 3.10] | 0.72 |
| Latest FUP | 2.67 [2.61 to 2.72] | 2.65 [2.58 to 2.71] | 2.73 [2.61 to 2.85] | 0.67 | 2.58 [2.50 to 2.67] | 2.72 [2.65 to 2.79] | 0.43 |
| Segment Length (mm) | |||||||
| Baseline | 36.1 [35.4 to 36.9] | 36.0 [35.1 to 36.8] | 36.6 [35.0 to 38.3] | 0.81 | 34.9 [33.7 to 36.1] | 36.9 [35.9 to 37.8] | 0.41 |
| 1-year | 36.7 [36.0 to 37.4] | 36.1 [35.3 to 36.9] | 38.8 [37.3 to 40.3] | 0.31 | 34.6 [33.5 to 35.7] | 38.0 [37.1 to 38.9] | 0.12 |
| Latest FUP | 33.7 [33.1 to 34.3] | 33.6 [33.0 to 34.3] | 33.8 [32.5 to 35.1] | 0.93 | 31.5 [30.6 to 32.4] | 35.1 [34.3 to 35.8] | 0.06 |
| Total Segment Length (mm) | |||||||
| Baseline | 456.4 [446.7 to 466.1] | 456.7 [445.6 to 467.9] | 455.1 [434.1 to 476.1] | 0.96 | 444.9 [429.2 to 460.5] | 463.8 [451.2 to 476.3] | 0.53 |
| 1-year | 463.7 [454.8 to 472.7] | 459.0 [448.8 to 469.2] | 480.5 [461.2 to 499.8] | 0.51 | 441.2 [427.0 to 455.4] | 478.1 [466.8 to 489.5] | 0.17 |
| Latest FUP | 426.4 [418.1 to 434.7] | 428.0 [418.5 to 437.5] | 420.6 [402.6 to 438.5] | 0.8 | 401.6 [388.6 to 414.7] | 442.2 [431.8 to 452.6] | 0.11 |
| Minimal Lumen Diameter (mm) | |||||||
| Baseline | 2.53 [2.49 to 2.57] | 2.55 [2.50 to 2.59] | 2.48 [2.39 to 2.56] | 0.64 | 2.61 [2.54 to 2.67] | 2.48 [2.43 to 2.54] | 0.34 |
| 1-year | 2.47 [2.41 to 2.53] | 2.44 [2.37 to 2.51] | 2.59 [2.46 to 2.71] | 0.5 | 2.56 [2.47 to 2.66] | 2.41 [2.34 to 2.49] | 0.41 |
| Latest FUP | 2.10 [2.05 to 2.14] | 2.09 [2.04 to 2.15] | 2.11 [2.01 to 2.21] | 0.94 | 2.11 [2.04 to 2.19] | 2.09 [2.03 to 2.15] | 0.87 |
| Δ* in MLD (1 year-BL) | -0.06 [-0.10 to -0.02] | -0.11 [-0.15 to -0.06] | 0.10 [0.02 to 0.19] | 0.15 | -0.04 [-0.10 to 0.02] | -0.07 [-0.12 to -0.02] | 0.8 |
| Δ* in MLD (FUP-BL) | -0.43 [-0.47 to -0.40] | -0.45 [-0.49 to -0.41] | -0.38 [-0.45 to -0.30] | 0.56 | -0.49 [-0.54 to -0.43] | -0.40 [-0.44 to -0.35] | 0.4 |
| Diameter Stenosis (%) | |||||||
| Baseline | 15.0 [14.7 to 15.3] | 14.7 [14.4 to 15.0] | 16.3 [15.7 to 17.0] | 0.13 | 13.6 [13.2 to 14.1] | 15.9 [15.6 to 16.3] | 0.01 |
| 1-year | 16.0 [15.67 to 16.4] | 15.6 [15.2 to 16.0] | 17.6 [16.9 to 18.4] | 0.12 | 15.1 [14.5 to 15.6] | 16.7 [16.2 to 17.1] | 0.16 |
| Latest FUP | 19.0 [18.6 to 19.5] | 18.2 [17.7 to 18.8] | 21.9 [20.9 to 22.9] | 0.04 | 15.9 [15.3 to 16.6] | 21.0 [20.5 to 21.5] | <0.01 |
| Δ* in %DS (1 year-BL) | 1.0 [0.7 to 1.3] | 0.9 [0.6 to 1.3] | 1.3 [0.7 to 2.0] | 0.72 | 1.4 [1.0 to 1.9] | 0.7 [0.3 to 1.1] | 0.43 |
| Δ* in %DS (FUP-BL) | 4.0 [3.6 to 4.4] | 3.6 [3.1 to 4.0] | 5.6 [4.8 to 6.4] | 0.15 | 2.3 [1.7 to 2.9] | 5.1 [4.6 to 5.5] | 0.02 |
Patient-level outcomes derived as the median (mm) and interquartile range. P-values using generalized linear mixed effect model taking random effects of patient-level data into account. QCA indicates quantitative coronary angiography; BL, baseline; FUP, follow-up; MLD, minimal lumen diameter; %DS, percent diameter stenosis; Δ, difference;
*Change was derived at the level of segments.