Table 3. Baseline clinical characteristics in patients with and without ISHLT-CAV at latest follow-up.
| ISHLT-CAV0 at latest follow-up n = 39 |
ISHLT-CAV1-3 at latest follow-up n = 38 |
p-value | Lower max %DS n = 39 |
Higher max %DS n = 38 |
p-value | |
|---|---|---|---|---|---|---|
| Recipient profile | ||||||
| Age (years) | 45.0 [26.0–54.0] | 55.5 [42.5–61.5] | 0.01 | 48.0 [22.0–56.5] | 53.0 [41.2–60.0] | 0.04 |
| Male | 28 (72) | 29 (76) | 0.85 | 27 (69) | 30 (79) | 0.48 |
| Body mass index, kg/m2 | 24.2 [22.5–26.4] | 24.1 [20.6–27.9] | 0.83 | 23.81 [21.5–26.2] | 24.3 [21.6–28.1] | 0.29 |
| CAD before HTx | 9 (23) | 18 (47) | 0.046 | 11 (28) | 16 (42) | 0.3 |
| Hypertension | 15 (38) | 15 (39) | 1 | 13 (33) | 17 (45) | 0.43 |
| HbA1c (%) | 5.6 [5.4–5.8] | 5.7 [5.4–6.1] | 0.12 | 5.5 [5.3–5.8] | 5.8 [5.6–6.1] | 0.004 |
| Active Smoker | 5 (13) | 4 (11) | 1 | 4 (10) | 5 (13) | 0.97 |
| eGFR (ml/min) | 70.2 [52.1–87.4] | 54.8 [39.4–66.8] | 0.005 | 68.2 [56.9–89.2] | 53.8 [39.4–69.3] | 0.002 |
| Hypercholesteremia | 16 (41) | 21 (55) | 0.31 | 18 (46) | 19 (50) | 0.91 |
| Total cholesterol (mmol/L) | 4.5 [4.0–5.8] | 5.2 [4.5–6.2] | 0.13 | 4.9 [4.0–5.8] | 5.2 [4.5–6.2] | 0.19 |
| HDL cholesterol (mmol/L) | 1.6 [1.2–2.1] | 1.5 [1.2–1.8] | 0.49 | 1.5 [1.2–1.9] | 1.6 [1.3–1.9] | 0.57 |
| LDL cholesterol (mmol/L) | 2.5 [2.1–3.7] | 3.2 [2.5–3.9] | 0.08 | 2.5 [2.1–3.6] | 3.2 [2.5–4.0] | 0.09 |
| Triglyceride (mmol/L) | 1.5 [1.1–2.0] | 2.3 [1.3–3.8] | 0.01 | 1.8 [1.1–2.4] | 2.0 [1.3–2.8] | 0.52 |
| CMV, donor pos./ recipient neg. | 8 (21) | 13 (34) | 0.27 | 10 (25) | 11 (29) | 0.94 |
| CMV infection | 12 (31) | 17 (45) | 0.3 | 12 (31) | 17 (45) | 0.3 |
| Severe TRS ≥ 2R | 0.00 [0.00–0.05] | 0.05 [0.00–0.09] | 0.005 | 0.00 [0.00–0.06] | 0.04 [0.00–0.09] | 0.03 |
| LVEF-FUP (%) | 65.0 [60.0–65.0] | 60.0 [60.0–65.0] | 0.07 | 65.0 [60.0–65.0] | 60.0 [60.0–65.0] | 0.19 |
| LVEDP (mmHg) | 12.5 [8.5–17.0] | 11.5 [6.0–15.0] | 0.25 | 13.0 [8.0–17.5] | 11.0 [6.0–14.0] | 0.13 |
| Donor profile | ||||||
| Age (years) | 38.5 [31.0–49.7] | 49.0 [39.0–57.5] | 0.009 | 42.0 [33.0–52.8] | 48.0 [36.2–55.5] | 0.16 |
| Male | 24 (62) | 32 (84) | 0.07 | 25 (64) | 31 (82) | 0.19 |
Values shown are median [lower to upper quartile] or number (%), p<0.05 was considered statistically significant; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; HDL, high-density lipoproteins; LDL, low-density lipoproteins; MLD, minimal lumen diameter; RVD, reference vessel diameter; CMV, cytomegalovirus; TRS, total rejection score; LVEF, left ventricular ejection fraction; FUP, follow-up, LVEDP, left ventricular end diastolic pressure.