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. 2018 Jul 30;10(8):2110–2129. doi: 10.1093/gbe/evy157

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© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 7. — —Evolutionary reconstruction of TTX resistance in SCN5A (Na_v1.5), SCN10A (Na_v1.8), and SCN11A (Na_v1.9) across amniote vertebrates. Tips and branches are color-coded by predicted TTX resistance, with warmer colors representing stronger resistance (see supplementary table S7, Supplementary Material online for details). Resistance-conferring substitutions found in Thamnophis sirtalis are plotted at their origin, with warmer colors indicating stronger resistance (supplementary table S7, Supplementary Material online). A nonresistant SCN5A-like paralog from Xenopus is used as the outgroup.