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Activity for compounds with HER2 based on (a) the DiscoverX scanELECT affinity (n = 2) assay and the (b) phosphorylation inhibition assay (n = 3). Compounds tested at 10 μM; lapatinib and erlotinib tested at 1 μM. (c) Inhibition of Src by dasatinib and ZINC01836093. (d) 2D representations for compounds showing erlotinib in green box consensus scaffolds circled in orange or cyan.
