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A model for the regulation of NHEJ by APCCdh1 in G1 cells. The DSBs in G1 cells are mainly repaired by Ku heterodimer-mediated NHEJ. RNF8-mediated polyubiquitination of histones activates the DNA damage signaling. However, RNF8 also induces polyubiquitination of Ku80, promoting dissociation of Ku80 from DSBs. In G1 phase, the destruction of RNF8 by active APCCdh1 complex suppresses the dissociation of Ku80 from DSBs, maintaining NHEJ in a highly active state.
