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. 2018 Jul 23;17(10):1268–1278. doi: 10.1080/15384101.2018.1475829

Figure 4.

Figure 4.

MiR-29a-5p inhibits the proliferation of EC-derived cells by targeting TPX2 (a-b) The proliferation of Ishikawa and KLE cells transfected with miR-29a-5p mimic and TPX2 siRNA (siTPX2) is significantly inhibited after 48 h, while that of miR-29a-5p inhibitor transfected cells is remarkably enhanced, as assessed by CCK-8 assay. (c-f) Exogenous miR-29a-5p over-expression or TPX2 silencing drastically reduce the number of EC-derived cell colonies formed, whereas miR-29a-5p down-regulation enhances the proliferation of Ishikawa and KLE cells, as assessed by colony formation assay. *p < 0.05, **p < 0.01, compared to NC.