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Effects of let-7e on activation of Akt. HCT-116 and LoVo human colorectal cancer cells were transfected with let-7e mimic or IGF1R siRNA for 48 h. The levels of total Akt (pan-Akt) and p-Akt (Thr308 and Ser473) were examined by Western blotting as described in the Methods section. Results shown are representative of at least three independent experiments.
