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. 2018 Aug 21;11:5035–5043. doi: 10.2147/OTT.S170439

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© 2018 Xu et al. This work is published and licensed by Dove Medical Press Limited

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miR-141 inhibitor reverses the inhibitory effect of XIST knockdown on PTC cell proliferation, cycle, migration, and invasion.

Notes: (A) qRT-PCR assay showed that XIST knockdown increased miR-141 expression, whereas miR-141 inhibition reversed it in the meantime. (B) CCK-8 assay showed that XIST knockdown inhibited TPC-1 cell proliferation, whereas miR-141 inhibition reversed it. (C–E) XIST knockdown increased cell cycle arrest at G1/G0 stage and decreased cell migration and invasion, whereas miR-141 inhibition in the meantime reversed these trends. *P<0.05, **P<0.01. Data are expressed as the mean ± SD of at least three independent experiments.

Abbreviations: XIST, X-inactive specific transcript; PTC, papillary thyroid carcinoma; qRT-PCR, quantitative real-time polymerase chain reaction; CCK, Cell Counting Kit; NC, negative control.