Table 3.
PARP Inhibitor (Generic Name) | Indication for Monitoring | Labs and Monitoring Schedule |
---|---|---|
Niraparib34 | Bone marrow suppression AML/MDS | Monitor CBC weekly for first month, then monthly for the following 11 months, then periodically |
Cardiovascular events | Monitor BP and HR monthly for first year of therapy, then periodically | |
Olaparib35 | Bone marrow suppression AML/MDS | Monitor CBC at baseline, then monthly |
Pneumonitis | Monitor for signs and symptoms of pneumonitis | |
Rucaparib37 | Bone marrow suppression AML/MDS | Monitor CBC at baseline, then monthly |
AML = acute myeloid leukemia; BP = blood pressure; CBC = complete blood count; HR = heart rate; MDS = myelodysplastic syndrome.