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The β4GalT-1 mutant Lec20 does not exhibit a fringe effect. (A) Fold-activation of normalized luciferase activity in Lec1 and Lec20 clones stably expressing vector, Mfng, or Lfng stimulated by J1 vs. L cells. Error bars represent SEM; n = 4. (B) Gel filtration profiles of [3H]fucose-labeled O-glycans released by β-elimination from Notch1 EGF19–23 produced by Lec20.Lfng (filled circles) or Lec20.vector (open squares). Elution positions of standard O-fucose glycans are indicated.
