Table 2.

O-fucose glycans that facilitate or modulate Notch signaling

Cells	Glycosylation defect	O-fucose glycans	Notch activation	Fringe effect
CHO (Pro−5)	β4GalT-6	SAα3Galβ4GlcNAcβ3Fuc-O-S/T	+	+
Lec1	GlcNAcT-1	SAα3Galβ4GlcNAcβ3Fuc-O-S/T	+	+
Lec2	CMP-SA transporter	Galβ4GlcNAcβ3Fuc-O-S/T	+	+
Lec8	UDP-Gal transporter	GlcNAcβ3Fuc-O-S/T	+	−
Lec13	GDP-4,6-dehydratase	S/T	↓	−
Lec20	β4GalT-1, β4GalT-6	GlcNAcβ3Fuc-O-S/T	+	−
Lec20 + GT	Corrected	SAα3Galβ4GlcNAcβ3Fuc-O-S/T	+	+