Table 1.

IQ scores for MAP1B LoF carriers compared with controls

IQ	n (MAP1B—Carriers/Controls)	Mean (SD) (MAP1B—Carriers/Controls)	β (95% CI)	P
Full-scale IQ	13/2226	68.3 (10.5)/102.1 (14.9)	−1.6 (−2.3, −0.9)	8.2 × 10−6
Performance IQ	10/2226	66.4 (9.3)/99.8 (15.2)	−1.6 (−2.4, −0.8)	6.4 × 10−5
Block design	9/1768	27.6 (5.8)/49.4 (10.5)	−1.7 (−2.5, −0.9)	3.1 × 10−5
Matrix reasoning	9/1768	31.4 (7.5)/49.7 (10.0)	−1.0 (−1.8, −0.2)	0.014
Verbal IQ	10/2226	74.5 (14.8)/103.5 (15.0)	−1.2 (−2.0, −0.4)	0.0039
Vocabulary	9/1767	33.2 (11.8)/52.3 (9.5)	−1.1 (−1.9, −0.3)	0.0082
Similarities	9/1768	34.0 (10.8)/51.5 (9.7)	−1.0 (−1.8, −0.2)	0.016

The IQ tests values are unadjusted means and standard deviation (SD). For analyses, the IQ test scores were inverse normal transformed, then shifted and scaled, resulting in controls having a mean of 0 and a standard deviation of 1. Lower IQ scores represent greater impairment in MAP1B LoF carriers. The effects (β in SD) and P-values were calculated by comparing MAP1B LoF carriers (FAM1-B1,-C1,-C2,-D1,-D2,-D3, FAM2-H1,-J2, FAM3-L1) with controls using a generalised least-squares regression with a variance–covariance matrix based on the kinship coefficient of each pair of individuals

SD: standard deviation