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. 2018 Aug 27;8:12894. doi: 10.1038/s41598-018-31150-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cortivazol and AZD2906 are more protective than Dex against acute TNF-induced SIRS in vivo. Female C57BL/6J mice aged 8 weeks were gavaged with 1 mg/kg Dex or an equimolar dose of Cortivazol or AZD2906 dissolved in 100 µl HPMC. One hour after gavage, the mice were injected intraperitoneally with 50 µg mTNF per 20 g bodyweight. Survival was monitored. None of the mice died after 72 h after the TNF challenge. Survival curves were compared with a Mantel-Cox test. Significant differences compared to HPMC (above survival curves) and Dex (indicated with dotted−) are given. P-values < 0.05, 0.01, 0.001 and 0.0001 are represented by *, **, *** or **** respectively. Non-significant differences are not indicated on the graph. Results of two pooled experiments are shown. HPMC: Hydroxypropylmethylcellulose, Dex: Dexamethasone, TNF: Tumor Necrosis Factor.