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. 2018 Aug 27;8:12894. doi: 10.1038/s41598-018-31150-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cortivazol and AZD2906 are retained longer in the mouse. CD1 female mice were gavaged with 100 µl of 1 mg/kg Dex, Cortivazol or AZD2906 dissolved in HPMC. Blood was collected by retro-orbital bleeding and the concentrations of the compounds in plasma were determined by mass spectrometry analysis. Data are shown as mean ± SEM. Significant differences of Cortivazol and AZD2906 compared to Dex are represented in the graph and calculated with and unpaired, two-tailed T test at the indicated time points. P-values < 0.05, 0.01, 0.001 and 0.0001 are represented with *, **, *** or **** respectively. Non-statistical differences are not indicated on the graph. Dex: Dexamethasone, C: Cortivazol, A: AZD2906, HPMC: Hydroxypropylmethylcellulose.