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. 2018 Aug 28;4:44. doi: 10.1038/s41421-018-0046-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Synaptic AMPAR-mediated currents (EPSC_AMPA) are unchanged between p47phox shRNA-transfected cells and neighbouring untransfected cells (n = 13 pairs). Individual data points represent individual pairs of neurons. Red circles represent mean ± SEM. b LTD is abolished in neurons transfected with p47phox shRNA (filled circle, n = 9), whilst LTD is induced in untransfected cells (open circle, n = 8). c Synaptic AMPAR-mediated currents (EPSC_AMPA) are unchanged between PKCζ shRNA-transfected cells and neighbouring untransfected cells (n = 16 pairs). Individual data points represent individual pairs of neurons. Red circles represent mean ± SEM. d LTD is abolished in neurons transfected with PKCζ shRNA (filled circle, n = 7), whilst LTD is induced in untransfected cells (open circle, n = 6). e Co-transfection of human p47phox with p47phox shRNA rescues the expression of LTD (filled circles, n = 7) to levels similar to untransfected cells (open circles, n = 7). f Immunoblots showing LFS-induced enhanced PKCζ phosphorylation at threonine 410 residue (pT410PKCζ; n = 5) and AP5 inhibition of LFS-induced pT410PKCζ (n = 5). g LTP was present in p47phox shRNA-transfected cells (filled circle, n = 7) and untransfected cells (open circle, n = 5). h LTP was readily induced in both PKCζ shRNA-transfected cells (filled circle, n = 7) and untransfected cells (open circle, n = 7). Data represents mean ± SEM. Asterisk (*) indicates statistical significance (p < 0.05)