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. 2018 Aug 27;8:12875. doi: 10.1038/s41598-018-30659-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Motor performances of SOD1(G93A) mice. The graphs show the motor performances of SOD1(G93A) mice treated with vehicle (VEH) or with the pharmacological combination of resveratrol and MS-275 at low or high doses (LD and HD, respectively). (a) Neurological Score test shows statistically significant differences comparing HD (black circle) with VEH (black square) groups (VEH vs HD, ^##P = 0.0153). (b) PaGE test shows a significant improvement of motor performance of LD (white triangle) and HD groups comparing to VEH mice (VEH vs LD, ^***P = 0.0007; VEH vs HD ^##P = 0.004). (c) Rotarod test shows a significant improvement of motor coordination of LD and HD groups starting from the 15th week. Note that the VEH group showed a faster decline of performances (VEH vs LD, ^***P = 0.0006; VEH vs HD ^#P = 0.0108). Results were analyzed by two-way ANOVA followed by Bonferroni multiple comparisons test. ^* was used to indicate differences between VEH and LD groups, while ^# was used to indicate differences between VEH and HD groups. Data in all graphs are expressed as mean ± SEM.