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. 2018 Aug 27;8:12875. doi: 10.1038/s41598-018-30659-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Number of MNs of the lumbar spinal cord of SOD1(G93A) mice. Treatment with epigenetic drugs increases the MNs survival in the lumbar spinal cord (L1-L5). (a–c) Nissl staining on the L5 segment of the spinal cord of VEH (n = 5) (a), LD (n = 5) (b) and HD (n = 5) (c) shows an increase of the numbers of MNs (arrows) in LD and HD mice compared to VEH. (d) 3D reconstruction of VEH lumbar spinal cord. (e) The graph shows the number of MNs population of the L1-L5 tract of the spinal cord of animal groups. Note a significant augment of the number of MNs population in a dose-dependent manner. Magnification 20×, scale bar 100 μm. Results were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test. Data are expressed as mean ± SEM. ^*p < 0.05, ^** p < 0.01, ^***p < 0.001.