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. 2018 Aug 27;8:12875. doi: 10.1038/s41598-018-30659-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histone 3 acetylation in the lumbar spinal cord of WT and SOD1(G93A) mice. The figure panel shows the different acetylation state of lysine 9 of histone 3 in the lumbar spinal cord of WT mice and VEH, LD and HD SOD1(G93A) groups (n = 4 per groups). The nuclei were stained in blue with DAPI (a,f,k,p) while, to identify MNs, the antibody neurofilament H was detected with SMI-32 antibody in green (b,g,l,q). The acetylation of histone 3, identified by H3Ack9 antibody in red was not present in VEH (h) and LD (m) groups compared to WT animals. The treatment with the epigenetic drugs restores the acetylation of histone 3 in HD group. Magnification 20×, scale bar 100 µm (a–d, f–i, k–n and p–s). In the last column (e,j,o,t) are shown the higher magnification of the boxed area showed in d, i, n and s respectively, scale bar 20 µm.