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. 2018 Aug 27;8:12882. doi: 10.1038/s41598-018-31071-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Autoradiogram of brain section images for the different treatment groups. (A) GSK-3 inhibitor alone with wild type mice (n = 3); (B) FUS sonication alone with transgenic mice (n = 6); (C) GSK-3 inhibitor with transgenic mice (n = 6); (D) combination of GSK-3 inhibitor and FUS with transgenic mice (n = 9); and quantification of 4 groups with (E) cortex (F) hippocampus. AR-alone and FUS-alone groups didn’t show plaque differences when analyzing cortex and hippocampus regions. However, the plaque-reduction effect could be revealed in AR + FUS group as measured in cortex (31.5% reduction; 3099.9 ± 311.6 LAU/mm² vs. 4526.2 ± 574.9 LAU/mm²; p = 0.0401) or hippocampus (25.6% reduction; 1248.1 ± 136.9 LAU/mm² vs. 1678.1 ± 207.1 LAU/mm²; p = 0.0159). WT = wild type; AR = AR-A014418; FUS = focused ultrasound.