Fig. 4.

Effects of the CF lung environment on Pseudomonas aeruginosa central carbon metabolism. Significant changes of the transcriptomic pattern between the in vitro- and in vivo-grown bacteria are reported. Transcripts, encoded enzymes, and catalyzed reaction (arrows) enriched during growth in CF lung are given in red, and decreased transcripts are indicated in blue. Genes and reactions not statistically significant are reported in black. Dashed lines connecting metabolic intermediates indicate that the reaction is carried out by multiple consecutive enzymes not reported