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. 2018 Aug 27;8:12922. doi: 10.1038/s41598-018-31306-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of KLHDC7B and STAR1 is significantly associated in breast cancer. Expression of KLHDC7B (A) and STAR1 (B) was examined by real-time RT-PCR in breast cancer tissue and its nearby normal tissue. The result is represented by 2^−ΔCt method and shown by box plots. Both genes were revealed to be upregulated in the cancer tissue with a statistical significance (P < 0.05) when tested by Mann-Whitney U-test. (C) The expression association between KLHDC7B and STAR1 in cancer tissue was examined using the coefficient of determination (R²) calculated by linear regression (R² = 0.3466, P < 0.01, N = 24).