FIGURE 1.

Representative images of histochemical characterization of lesions with ferric hematoxylin. Acute active plaque arround a vessel where no completely loss of myelin was found in a male patient of 58 years old (a). Extravasated mononucleated cells in acute active plaque of the same patient. Scale bar: 10 μm (100×) (b). Chronic active plaque with three characteristic areas in a female patient of 48 years old: periplaque WM, border area, and inactive center plaque. Scale bar 50 μm (4×) (c). Macrophages around vessels in chronic active plaque edge (arrows). Scale bar: 50 μm (20×) (d). Chronic active plaque with remyelination in a male patient of 58 years old, shadow plaques are also observed (arrowheads). Scale bar 50 μm (4×) (e).