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. 2018 Aug 21;10:254. doi: 10.3389/fnagi.2018.00254

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Copyright © 2018 Navarro, Rioseras, del Valle, Martínez-Pinilla, Astudillo and Tolivia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Double immunohistochemical technique for Apo D (blue) and NF-200 (brown). The representative micrographs show a chronic plaque where it can be clearly distinguish the surveyed areas: periplaque WM area (a), active area (b), inactive area (c), and remyelination area (d). Scale bar: 60 μm. Histogram showing densitometric quantification of Apo D (e). Histogram showing densitometric quantification of NF-200 (f). Bars represent mean density in 20× field ± SEM. ^∗∗∗Statistically significant differences versus periplaque WM, p < 0.001. ^###Statistically significant differences inactive center versus active area, p < 0.001. AU: arbitrary units.