Table 1.

Demographic data of patients.

Case	Age	Sex	Cause of death	Time postmortem	Type of MS	Number of samples	Brain area	Type of lesion
1	58	Male	Cardiogenic shock	<12 h	PPMS	1	Periventricular WM	A big chronic-active plaque and little active plaques
2	65	Female	Cardiorespiratory arrest	<12 h	SPMS	1	Periventricular WM	Chronic-active plaques with remyelination
3	48	Female	Cardiorespiratory arrest	<12 h	Long-term SPMS	1	Subcortical WM of the temporal lobe	Chronic-active plaques
4	46	Male	Multiorgan failure	<12 h	PPMS	1	Periventricular WM	Chronic-active plaques
5	68	Male	Multiorgan failure	<12 h	SPMS	1	Periventricular WM	Chronic-active plaques with remyelination
6	52	Female	Cardiorespiratory arrest	<12 h	SPMS	1	Periventricular WM	Chronic-active plaques
7	64	Male	Acute myocardial infarction	<12 h	Long-term SPMS	1	Periventricular WM	Chronic-active plaques with remyelination
8	?	?		<12 h	Long-term SPMS	1	Subcortical WM of the temporal lobe	Chronic-active plaques
9	27	Female	Multiorgan failure	6–12 h	Long-term SPMS	3	Subcortical WM of the frontal lobe, brain stem, spinal cord	Little active plaques
10	38	Male	Respiratory failure	6–12 h	SPMS	3	Subcortical WM of the frontal and parietal lobes, spinal cord	Chronic-active plaques
11	36	Female	Multiorgan failure	6–12 h	Long-term SPMS	3	Subcortical WM of the frontal, parietal and temporal lobes	Chronic inactive plaques
12	79	Male	Multiorgan failure	6–12 h	Control	1	Spinal cord
13	66	Male	Cardiorespiratory arrest	<12 h	Control	1	Periventricular WM
14	65	Male	Cardiorespiratory arrest	<12 h	Control	1	Subcortical WM of the occipital lobe

MS, multiple sclerosis; PPMS, primary progressive MS; SPMS, secondary progressive MS; WM, white matter.