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. 2018 Aug 21;9:899. doi: 10.3389/fphar.2018.00899

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Copyright © 2018 Barbieri, Würth, Pattarozzi, Verduci, Mazzola, Cattaneo, Tonelli, Solari, Bajetto, Daga, Vicentini, Mazzanti and Florio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of biguanides on the viability of cells in which CLIC1 associated membrane current is not relevant for cell proliferation. Concentration-response curves of metformin (MET), phenformin (PHEN), cycloguanil (CG), moroxydine (MOR), and proguanil (PG) in differentiated GBM cells (A) and ucMSCs (B). Cell viability was assessed by MTT reduction test, after 48 h of treatment. Data are the mean of n = 3 experiments performed in quadruplicate, on cells derived from 5 GBMs (for metformin: GBM1, 2, 3, 4, 6, 7) and 3 GBMs (for phenformin, cycloguanil, moroxydine, and proguanil: GBM2, 3, 4) and 4 independent ucMSC cultures. For sake of clarity statistical significance is reported in Supplementary Table S1. The comparison of the effects of biguanides in GSCs and differentiated cells from the same GBM is reported in Supplementary Figure S6.