FIGURE 2.

Flavivirus life cycle. Flavivirus enter in the host cell by receptor-mediated endocytosis. Acidification of the endosomal vesicle leads to the fusion of the viral and cell membranes, enabling the release of the viral genome ss(+)RNA into the cytosol. The ss(+)RNA is translated into a polyprotein that is processed by viral and host proteases, originating seven non-structural and three structural proteins (not shown). Virus replication and assembly occur near the ER and LDs. After virion maturation by the host protease furin, the mature virion follows the secretion pathway and is subsequently released by exocytosis.