Table 6.
Quantification of brain volume in DM2.
| Study | Modality | Estimated parameters | Group size (MRI done) | Age (M ±SD) [years] | Age at onset [years] | Disease duration (M ±SD) [years] | Correlation parameters |
|---|---|---|---|---|---|---|---|
| Kassubek et al. (52) | 1.5T (T1) | BPF | 9 (9) | 53 ± 11 | - | 26 ± 16 | Age (+), disease duration, motor score, educational level |
| Minnerop et al. (87) | 1.5T (T1) | BPF VBM (WM, GM), SBM (callosal thickness) | 13 (13) | 53.3 ± 12.0 | - | 12.0 ± 8.8 | - |
| Weber et al. (33) | 1.5T (T1, T2, FLAIR) | BPF, VBM (GM) | 9 (9) | 53.4 ± 10.9 | - | 23.0 ± 15.0 | Age (+), disease duration, NPT (+) |
| Minnerop et al. (11) | 3T (T1) | VBM (GM, WM) | 22 | 52.5 ± 10.1 | - | 11.9 ± 9.9 | - |
| Franc et al. (57) | 3T (T1) | DTI (GM volume) | 5 (5) | 38–49 | 29.5 | - | Masticatory muscle, FA decrease (+) |
| Schneider-Gold et al. (41) | 3T (T1) | VBM (GM, WM), volumentry (total GM/WM, cerebellum, brainstem, upper cervical cord, ventricle) | 16 (15) | 52 ± 7* | 24–49 | 14 ± 9* | NPT (+), depression (+), daytime sleepiness (+), MIRS |
All included studies investigated patients in comparison with controls. BPF, brain parenchymal fraction; CSF, cerebrospinal fluid; CT, cortical thickness; DTI, diffusion tensor imaging; GM, gray matter; MIRS, muscular impairment rating scale; NPT, neuropsychological tests; SBM, surface-based morphometry; VBM, voxel-based morphometry; WM, white matter; (+), positive or negative correlation was found;
*
data refer to whole DM2 study group, including patients that did not undergo MRI.