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. 2018 Aug 21;9:1082. doi: 10.3389/fphys.2018.01082

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Copyright © 2018 Zhou, Wang, Huang, Yuan, Sheng, Yu, Meng, Wang, Po and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in ERP and ΣWOV. (A–G) The ERP changes at different time points in the control group, RAP group, NRG1 group and NRG1 + ERA group. (H) The ΣWOV changes at different time points in the four groups. The ERP was shortened, and ΣWOV was widened in atrial and pulmonary vein sites in the RAP group. NRG1 alleviated the effect of RAP, and ERA blocked the beneficial effects of NRG1 on ERP and ΣWOV. ^∗p < 0.05 vs. NRG1 group. ^#p < 0.05 vs. RAP group. ^ΔP < 0.05 vs. the NRG1 group.