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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Melanoma Res. 2018 Oct;28(5):390–397. doi: 10.1097/CMR.0000000000000474

Figure 5. Treatment of the A375 vemurafenib-resistant melanoma cell line with MLN4924 leads to cell death.

Figure 5

Wild-type A375 cells, vemurafenib resistant A375 cells (A375 Vem, in vitro acquired resistance) or vemurafenib resistant M308 cells (innate resistance) were treated for 72 hours with increasing doses of MLN4924 (0 nM, 100 nM, 1200 nM, 2000 nM). Apoptosis levels were obtained through flow cytometric analysis. Data is presented as mean ± S.E.M. *p<0.05, ***p<0.0005