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. Author manuscript; available in PMC: 2019 Sep 15.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 20;1095:112–118. doi: 10.1016/j.jchromb.2018.07.017

Figure 3. Evaluation of plasma matrix effects.

Figure 3

(A) A 4.0 μL injection of processed pooled plasma in 0.1% formic acid in water was injected onto the C18 column. During injection, a solution of dns-HGA (top, gray, dashed) and dns-MCPG (bottom, black, solid) was infused post-column. No significant plasma matrix effects were observed at the expected retention times of 4.28 ± 0.03 minutes for dns-HGA and 3.88 ± 0.03 minutes for dns-MCPG. (B) For comparison, the same experiment was performed, with 4.0 μL of solvent blank (0.1% formic acid) injected onto the column during the infusion.