Table 1.
Demographic and clinical characteristics for the sample.
| MDD (N=35) | HC (N=26)a | |||
|---|---|---|---|---|
| N | % | N | % | |
| Female | 21 | 60.0 | 16 | 61.5 |
| Race (Caucasian) | 32 | 94.1 | 19 | 73.1 |
| History of Psychiatric Hospitalization | 19 | 54.3 | ||
| History of Suicide Attempt | 14 | 40.0 | ||
| History of Substance Abuse | 8 | 22.9 | ||
| Family History | N | % | ||
| - Alcohol Abuse (First Degree) | 13 | 37.1 | ||
| - Anxiety Disorder | 12 | 34.3 | ||
| - Mood Disorder | 25 | 71.4 | ||
| - Suicide Attempt | 6 | 17.7 | ||
| Mean | SD | Mean | SD | |
| Age | 35.5 | 9.6 | 33.9 | 10.4 |
| Age of Onset | 15.8 | 6.6 | ||
| Length of Current Episode (Months) | 41.4 | 68.0 | ||
| Mean number of failed trials (Lifetime, N=34)b | 6.4 | 3.4 | ||
| MADRS | 33.4 | 4.7 | 1.5 | 1.6 |
| HDRS | 21.6 | 4.3 | 1.6 | 1.4 |
| BDI | 29.0 | 7.6 | 0.2 | 0.6 |
| CADSS | 2.8 | 4.5 | 0.0 | 0.0 |
| BPRS Positive | 10.1 | 1.9 | 8.0 | 0.2 |
| HAMA | 22.6 | 6.3 | 1.4 | 1.3 |
| SHAPS | 39.5 | 3.9 | 18.5 | 4.3 |
| SSI (5 Items) | 1.6 | 1.8 | 0.0 | 0.0 |
| TEPS Consummatory | 23.4 | 4.6 | 39.6 | 5.2 |
| TEPS Anticipatory | 23 | 7.3 | 46.9 | 5.5 |
| PCLC | 42 | 12.3 | 17.6 | 1.1 |
| QLESQ | 30.8 | 7.2 | 64.1 | 5.2 |
Note that one healthy control subject was excluded prior to infusion and thus only baseline MEG recordings are included in the analysis. Mean values on rating scales are given for N=25.
All patients had failed to respond to at least one antidepressant trial in the current episode.
MDD subjects and healthy controls did not differ on the basis of age or gender composition (p>0.05).
MDD: major depressive disorder; HC: healthy control; MADRS: Montgomery Åsberg Depression Rating Scale; HAM-D: Hamilton Depression Rating Scale; BDI: Beck Depression Inventory; BPRS: Brief Psychiatric Rating Scale; CADSS: Clinician-Administered Dissociative States Scale; HAM-A: Hamilton Anxiety Rating Scale; SHAPS: Snaith-Hamilton Pleasure Scale; SSI: Scale for Suicide Ideation; TEPS: Temporal Experience of Pleasure Scale; PCLC: PTSD Checklist, Civilian Version; QLESQ: Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form.