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. Author manuscript; available in PMC: 2019 Jul 31.

Published in final edited form as: Circulation. 2018 Jul 31;138(5):513–526. doi: 10.1161/CIRCULATIONAHA.117.031635

Table 1.

Characterization of Heart Failure After Two and Eight Weeks of TAC

	Sham	2 wks TAC	8 wks TAC
Mass
Total body weight (g)	28.9 ± 0.7	25.7 ± 1^*	25.1 ± 3.1^*
LV mass (mg)	84 ± 7	149 ± 9^*	208 ± 15^*^†
Lung mass (mg)	142 ± 7	324 ± 66^*	471 ± 52^*^†
Tibia length (mm)	17.5 ± 0.1	17.6 ± 0.2	17.7 ± 0.2
LV/TL (mg/mm)	4.8 ± 0.5	8.5 ± 0.5^*	11.8 ± 0.9^*^†
Lung/TL (mg/mm)	8.1 ± 0.4	18.4 ± 3.6^*	26.7 ± 3.1^*^†
Hemodynamic data
Peak systolic pressure (mmHg)	97 ± 7	138 ± 23^*	113 ± 23
End diastolic pressure (mmHg)	4 ± 2	20 ± 4^*	30 ± 5^*^†
dP/dT max (mmHg/sec)	8289 ± 681	6178 ± 1357^*	4272 ± 1104^*^†
dP/dT min (mmHg/sec)	−8397 ± 664	−6050 ± 1272^*	−4261 ± 1223^*^†
Ejection fraction (%)	63 ± 6	40 ± 2^*	25 ± 4^*^†
Heart rate (bpm)	523 ± 10	526 ± 22	533 ± 50

Means±SD. p<0.05:

^*

vs. Sham;

^†

vs. 2 wks TAC