Table 3.

Characterization of Heart Failure in Mice Treated with Recombinant Mouse BMP9

	Veh Sham	Veh TAC	rmBMP9 Sham	rmBMP9 TAC
Mass
Total body weight (g)	31.9 ± 0.4	25.2 ± 3.5*	31.9 ± 2.2	28.9 ± 1.4 ‡
LV mass (mg)	93 ± 2	221 ± 10*	88 ± 4	178 ± 24 †‡
Lung mass (mg)	169 ± 19	432 ± 91*	154 ± 6	239 ± 119 ‡
Tibia length (mm)	17.8 ± 0.2	17.7 ± 0.1	18.1 ± 0.1	17.9 ± 0.3
LV/TL (mg/mm)	2.9 ± 0.1	8.9 ± 1.1*	2.7 ± 0.1	6.2 ± 0.7 †‡
Lung/TL (mg/mm)	5.2 ± 0.1	12.5 ± 0.5*	4.8 ± 0.2	9.9 ± 1.2 †‡
Hemodynamic data
Peak systolic pressure (mmHg)	95 ± 4	124 ± 24	97 ± 1	148 ± 19 ‡
End diastolic pressure (mmHg)	5 ± 3	28 ± 3*	3 ± 2	11 ± 4 †‡
dP/dT max (mmHg/sec)	9076 ± 1481	5752 ± 872*	9289 ± 755	7636 ± 1157 †‡
dP/dT min (mmHg/sec)	−9066 ± 1140	−5157 ± 1470*	−9541 ± 546	−7398 ± 1318 †‡
Ejection fraction (%)	61 ± 6	23 ± 3*	60 ± 9	44 ± 7†‡
Heart rate (bpm)	509 ± 69	587 ± 67	556 ± 39	572 ± 16

Means±SD. p<0.05:

^*vs. Vehicle Sham;

^†vs. rBMP9 Sham;

^‡vs. Vehicle TAC