Table 3.
Comet assay parameters in liver and testes cells of treated male mice with bisphenol-A (BPA) and/or pumpkin seed oil (PSO) for 28 consecutive days.
Treatments | Tail length (μm) |
Tail DNA (%) |
Olive tail moment (μm) |
|||
---|---|---|---|---|---|---|
Liver | testes | Liver | testes | Liver | testes | |
Control | 7.66 ± 0.80e | 6.73 ± 0.46e | 13.53 ± 0.51c | 14.26 ± 0.20e | 1.03 ± 0.08d | 0.98 ± 0.11e |
Vehicle | 8.56 ± 0.41de | 7.26 ± 0.30cde | 13.15 ± 0.22c | 15.00 ± 0.50de | 1.12 ± 0.04cd | 1.09 ± 0.08de |
PSO(1 mL/kg b.w.) | 8.38 ± 0.37e | 7.20 ± 0.33de | 11.82 ± 0.71d | 14.70 ± 0.52de | 0.99 ± 0.05d | 1.05 ± 0.03de |
BPA(50 mg/kg b.w.) | 17.30 ± 1.08a | 9.83 ± 0.15a | 19.93 ± 0.68a | 23.56 ± 0.45a | 3.63 ± 0.52a | 2.37 ± 0.05a |
PSO before BPA | 9.66 ± 0.23cd | 7.50 ± 0.30cd | 13.57 ± 0.65c | 15.36 ± 0.56cd | 1.31 ± 0.03cd | 1.15 ± 0.03d |
PSO with BPA | 11.80 ± 0.50b | 8.70 ± 0.20b | 15.36 ± 1.02b | 17.43 ± 0.31b | 1.85 ± 0.08b | 1.51 ± 0.05b |
PSO after BPA | 10.00 ± 0.78c | 7.83 ± 0.40c | 14.86 ± 0.15b | 15.80 ± 0.26c | 1.48 ± 0.10bc | 1.26 ± 0.01c |
Data are expressed as means ± SD. Mean values in the same column within each parameter bearing the same superscript do not differ significantly (P≤ 0.05).