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Screening for hypoxia modulating drugs. a Schematic diagram showing the screening assay protocol for hypoxia modulating drugs. b HIF-1α-driven Luciferase assay for U2OS cells stably transfected with HRE-luciferase plasmid. c HIF-reporter assay in cells treated with natural drugs (5.0 mM). Out of the 57 drugs tested, 5 compounds (shown by dark bars) showed strong pro-hypoxia activity and 4 compounds (shown by white bars) showed anti-hypoxia activity
