Fig. 2.

HIF-1α-driven pro-hypoxia effect of CAPE on U2OS. a Effect of CAPE on HIF-1α-driven luciferase reporter assays in comparison to a standard hypoxia inducing drug, CoCl2. b–d Effect of CAPE on the luciferase transcript (b) and protein as detected by immunostaining (c) and Western blotting with anti-luciferase specific antibody (d). e Effect of CAPE on endogenous HIF-1α protein; CoCl2 was used as positive control