Fig. 3.

Chemical structures. a Caffeic acid phenethyl ester (CAPE). b Caffeic acid methyl ester (CAME). c Binding of CAPE and FIH-1. Interactions of CAPE (shown in pink) and FIH-1 in the presence of OGA (shown in green). Two hydrogen bonds are formed: one between Asp201 and CAPE molecule and the other between OGA and CAPE molecule. d Interactions of CAPE (shown in pink) and FIH-1 in the absence of OGA. CAPE is involved in hydrogen bond formation with Ser91 and Tyr93. e Binding of CAME and FIH-1. Interactions of CAME (shown in pink) and FIH-1 in the presence of OGA (shown in green). Two hydrogen bonds are formed between Asp201 and CAME molecule. f Interactions of CAME (shown in pink) and FIH-1 in the absence of OGA. Two hydrogen bonds are formed between Arg238 and CAME, and one hydrogen bond is formed between Gln239 and CAME molecule